An internal standard for the quantification of sotalol
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Unlabeled Version(s)
16136Sotalol (hydrochloride)
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Sotalol-d6 (hydrochloride)

Item No. 29097

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-(1-hydroxy-2-((propan-2-yl-1,1,1,3,3,3-d6)amino)ethyl)phenyl)methanesulfonamide, monohydrochloride
CAS Number
1246820-85-8
Synonyms
  • MJ1999-d6
  • (±)-Sotalol-d6
  • DL-Sotalol-d6
Molecular Formula
C12H14D6N2O3S • HCl
Formula Weight
314.9
Purity
≥99% deuterated forms (d1-d6);
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: solubleWater: soluble
SMILES
CS(NC1=CC=C(C(O)CNC(C([2H])([2H])[2H])C([2H])([2H])[2H])C=C1)(=O)=O.Cl
InChi Code
InChI=1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H/i1D3,2D3;
InChi Key
VIDRYROWYFWGSY-TXHXQZCNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    5 mg

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    Product Description

    Sotalol-d6 is intended for use as an internal standard for the quantification of sotalol (Item No. 16136) by GC- or LC-MS. Sotalol is a non-selective antagonist of β-adrenergic receptors (β-ARs; IC50s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent.1,2 It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles when used at a concentration of 100 μM.3 Sotalol decreases heart rate and increases blood pressure and the cardiac functional refractory period (FRP) in a canine model of ventricular tachycardia induced by programmed electrical stimulation (PES).1 Formulations containing sotalol have been used in the treatment of ventricular arrhythmias and maintenance of normal sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lis, R., Morgan, T.K., Jr., Marisca, A.J., et al. Synthesis of novel (aryloxy) propanolamines and related compounds possessing both class II and class III antiarrhythmic activity. J. Med. Chem 33(10), 2883-2891 (1990).

    2. Antonaccio, M.J., and Gomoll, A. Pharmacology, pharmacodynamics and pharmacokinetics of sotalol. Am. J. Cardiol. 65(2), 12A-21A (1990).

    3. Komeichi, K., Tohse, N., Nakaya, H., et al. Effects of N-acetylprocainamide and sotalol on ion currents in isolated guinea-pig ventricular myocytes. Eur. J. Pharm. 187(3), 313-322 (1990).