A coordination complex of zinc and pyrithione
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Zinc Pyrithione

Item No. 29154

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(T-4)-bis[1-(hydroxy-κO)-2(1H)-pyridinethionato-κS2]-zinc
CAS Number
13463-41-7
Molecular Formula
C10H8N2O2S2Zn
Formula Weight
317.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2.5 mg/mlDMSO: 30 mg/ml
λmax
216, 244, 275 nm
SMILES
N12[O-][Zn+2]3([S]=C1C=CC=C2)[O-]N(C=CC=C4)C4=[S]3
InChi Code
InChI=1S/2C5H4NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4H;/q2*-1;+2
InChi Key
PICXIOQBANWBIZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 mg

    $28

    Add
    Cayman Chemical
    Visit Our Environmental Toxicology Resource Center

    Explore additional resources to study natural toxins, pollutants including PFAS and 6-PPD-Q, and their biological effects.

    ENVIRONMENTAL TOXICOLOGY TOOLS & SERVICES
    Product Description

    Zinc pyrithione is a coordination complex of zinc and pyrithione that has antimicrobial, anticancer, and fungicidal activities.1,2,3,4 It is active against the bacteria E. coli, S. aureus, K. pneumoniae, A. baumannii, P. aeruginosa, E. faecium, E. faecalis, and E. cloacae (MICs = 1-4 µg/ml) and the fungus P. ovale when used at concentrations ranging from 0.01 to 10 µg/ml.1,2 Zinc pyrithione reduces tumor growth in an SCC-4 mouse xenograft model when administered at a dose of 1 mg/kg per week for six weeks.3 Topical application of zinc pyrithione (0.5-5% w/w) completely prevents Aspergillus growth in soy meal-derived adhesives.4 Formulations containing zinc pyrithione have been used in the treatment of dandruff and in the prevention of fungal growth in industrial applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Blanchard, C., Brooks, L., Ebsworth-Mojica, K., et al. Zinc pyrithione improves the antibacterial activity of silver sulfadiazine ointment. mSphere 1(5), e00194-00116 (2016).

    2. Van Cutsem, J., Van Gerven, F., Fransen, J., et al. The in vitro antifungal activity of ketoconazole, zinc pyrithione, and selenium sulfide against Pityrosporum and their efficacy as a shampoo in the treatment of experimental pityrosporosis in guinea pigs. J. Am. Acad. Dermatol. 22(6 Pt 1), 993-998 (1990).

    3. Srivastava, G., Matta, A., Fu, G., et al. Anticancer activity of pyrithione zinc in oral cancer cells identified in small molecule screens and xenograft model: Implications for oral cancer therapy. Mol. Oncol. 9(8), 1720-1735 (2015).

    4. Li, W., Chen, M., Li, Y., et al. Improving mildew resistance of soy meal by nano-Ag/TiO2, zinc pyrithione and 4-cumylphenol. Polymers (Basel) 12(1), 169 (2020).

    Product Citations

    Du, W., Gu, M., Hu, M., et al. Lysosomal Zn2+ release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma. Cell Rep. 37(3), 109848 (2021).