A Smoothened receptor antagonist
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MK-4101

Item No. 29159

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(3,3-difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-1,2,4-oxadiazole
CAS Number
935273-79-3
Molecular Formula
C24H24F5N5O
Formula Weight
493.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:8): 0.11 mg/ml
SMILES
CN1C(C2=C(C(F)(F)F)C=CC=C2)=NN=C1C34CCC(CC4)(C5=NOC(C6CC(F)(F)C6)=N5)CC3
InChi Code
InChI=1S/C24H24F5N5O/c1-34-17(15-4-2-3-5-16(15)24(27,28)29)31-32-20(34)22-9-6-21(7-10-22,8-11-22)19-30-18(35-33-19)14-12-23(25,26)13-14/h2-5,14H,6-13H2,1H3
InChi Key
HKJOIWLYDJCTQR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $186

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    10 mg

    $332

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    25 mg

    $775

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    Product Description

    MK-4101 is a Smoothened (Smo) receptor antagonist.1 It binds to human recombinant Smo expressed in HEK293T cells (IC50 = 1.1 µM) and inhibits Gli1-mediated hedgehog signaling in a reporter assay (IC50 = 1.5 µM). It is also an inhibitor of 11β-hydroxy steroid dehydrogenase-1. MK-4101 (40 and 80 mg/kg per day) reduces tumor growth in a murine medulloblastoma mouse allograft model, induces tumor regression when administered at a dose of 80 mg/kg twice per day, and reduces expression of the hedgehog pathway-associated transcription factor Gli1 in tumor tissue.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Filocamo, G., Brunetti, M., Colaceci, F., et al. MK-4101, a potent inhibitor of the Hedgehog pathway, is highly active against medulloblastoma and basal cell carcinoma. Mol. Cancer Ther. 15(6), 1177-1189 (2016).