An mGluR antagonist
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HexylHIBO (hydrobromide)

Item No. 29164

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-amino-4-hexyl-2,3-dihydro-3-oxo-5-isoxazolepropanoic acid, monohydrobromide
Synonyms
  • Hexylhomoibotenic Acid
Molecular Formula
C12H20N2O4 • HBr
Formula Weight
337.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C1C(CCCCCC)=C(CC(N)C(O)=O)ON1.Br
InChi Code
InChI=1S/C12H20N2O4.BrH/c1-2-3-4-5-6-8-10(18-14-11(8)15)7-9(13)12(16)17;/h9H,2-7,13H2,1H3,(H,14,15)(H,16,17);1H
InChi Key
QIOWURBHVRRTJR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $138

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    5 mg

    $413

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    10 mg

    $688

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    Product Description

    HexylHIBO is an antagonist of group I metabotropic glutamate receptors (mGluRs; Kbs = 140 and 110 µM for mGluR1α and mGluR5a, respectively).1 It is selective for group I mGluRs over mGluR2 (group II) and mGluR4a (group III) (Kbs = >1,000 µM for both), as well as AMPA, NMDA, and kainate receptors (IC50s = >100 µM for all). HexylHIBO (6.3 and 12.5 mg/kg, i.c.v.) inhibits NMDA-induced seizures in mice. It also potentiates increases in plasma adrenocorticotropic hormone (ACTH) levels in a rat model of restraint stress.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Madsen, U., Bräuner-Osborne, H., Frydenvang, K., et al. Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors. J. Med. Chem. 44(7), 1051-1059 (2001).

    2. Evanson, N.K., and Herman, J.P. Metabotropic glutamate receptor-mediated signaling dampens the HPA axis response to restraint stress. Physiol. Behav. 150, 2-7 (2015).