FG-7142

FG-7142 is a benzodiazepine receptor ligand with anxiogenic and proconvulsant properties.¹ It increases benzodiazepine receptor ligand binding and GABA-dependent chloride uptake in primary chick cerebral cortical neurons when used at a concentration of 1 μM. FG-7142 (5 mg/kg) decreases pinning of the other animal and increases avoiding behavior in rats, an effect that can be prevented by the benzodiazepine receptor antagonist Ro 15-1788 (flumazenil; Item No. 14252).² It reduces the infused pentylenetetrazol (PTZ; Item No. 18682) seizure threshold and induces generalized seizures in mice when administered at doses of 10 and 40 mg/kg, respectively.³ FG-7142 (3.75, 7.5, and 15 mg/kg, i.p.) also decreases food and water intake, eating rate, and time spent in the open arms of the elevated plus maze in female rats.⁴

WARNING This product is not for human or veterinary use.

1. Miller, L.G., Heller, J., Lumpkin, M., et al. Augmentation of GABA_A receptor function by chronic exposure to GABA-neutral and GABA-negative benzodiazepine ligands in cultured cortical neurons. Biochem. Pharmacol. 40(6), 1337-1344 (1990).

2. Beck, C.H., and Cooper, S.J. β-Carboline FG 7142-reduced aggression in male rats: Reversed by the benzodiazepine receptor antagonist, Ro15-1788. Pharmacol. Biochem. Behav. 24(6), 1645-1649 (1986).

3. Little, H.J., Nutt, D.J., and Taylor, S.C. Acute and chronic effects of the benzodiazepine receptor ligand FG 7142: Proconvulsant properties and kindling. Br. J. Pharmacol. 83(4), 951-958 (1984).

4. Cottone, P., Sabino, V., Steardo, L., et al. FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: Evidence that benzodiazepine inverse agonists reduce food palatability. Neuropsychopharmacology 32(5), 1069-1081 (2007).