A benzodiazepine receptor ligand
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FG-7142

Item No. 29183

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide
CAS Number
78538-74-6
Synonyms
  • ZK 39106
Molecular Formula
C13H11N3O
Formula Weight
225.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 1 mg/ml
λmax
217, 235, 271 nm
SMILES
O=C(NC)C1=NC=C2C(C3=C(C=CC=C3)N2)=C1
InChi Code
InChI=1S/C13H11N3O/c1-14-13(17)11-6-9-8-4-2-3-5-10(8)16-12(9)7-15-11/h2-7,16H,1H3,(H,14,17)
InChi Key
QMCOPDWHWYSJSA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $103

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    100 mg

    $169

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    Product Description

    FG-7142 is a benzodiazepine receptor ligand with anxiogenic and proconvulsant properties.1 It increases benzodiazepine receptor ligand binding and GABA-dependent chloride uptake in primary chick cerebral cortical neurons when used at a concentration of 1 μM. FG-7142 (5 mg/kg) decreases pinning of the other animal and increases avoiding behavior in rats, an effect that can be prevented by the benzodiazepine receptor antagonist Ro 15-1788 (flumazenil; Item No. 14252).2 It reduces the infused pentylenetetrazol (PTZ; Item No. 18682) seizure threshold and induces generalized seizures in mice when administered at doses of 10 and 40 mg/kg, respectively.3 FG-7142 (3.75, 7.5, and 15 mg/kg, i.p.) also decreases food and water intake, eating rate, and time spent in the open arms of the elevated plus maze in female rats.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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