An oxidized form of mitoquinol
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Mitoquinone (mesylate)

Item No. 29317

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[10-(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl]triphenyl-phosphonium, monomethanesulfonate
CAS Number
845959-50-4
Synonyms
  • ​MitoQ
Molecular Formula
C37H44O4P • CH3O3S
Formula Weight
678.8
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol:water (1:1)
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
O=C(C(OC)=C1OC)C(CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)=C(C)C1=O.O=S(C)([O-])=O
InChi Code
InChI=1S/C37H44O4P.CH4O3S/c1-29-33(35(39)37(41-3)36(40-2)34(29)38)27-19-8-6-4-5-7-9-20-28-42(30-21-13-10-14-22-30,31-23-15-11-16-24-31)32-25-17-12-18-26-32;1-5(2,3)4/h10-18,21-26H,4-9,19-20,27-28H2,1-3H3;1H3,(H,2,3,4)/q+1;/p-1
InChi Key
GVZFUVXPTPGOQT-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $32

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    5 mg

    $86

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    10 mg

    $156

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    25 mg

    $271

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    Product Description

    Mitoquinone is an oxidized form of mitoquinol (Item No. 89950).1 It is reduced to mitoquinol in isolated bovine heart mitochondrial membranes using succinate for respiration when used at a concentration of 50 µM. Mitoquinone (0.01-10 µM) increases the rate of hydrogen peroxide formation in isolated bovine aortic endothelial cells (BAECs).2 It induces cell death in isolated mouse pancreatic acinar cells when used at a concentration of 1 µM.3 Mitoquinone, in combination with mitoquinol, reduces malondialdehyde (MDA) levels in isolated rat liver mitochondria and decreases caspase activity in Jurkat cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kelso, G.F., Porteous, C.M., Hughes, G., et al. Prevention of mitochondrial oxidative damage using targeted antioxidants. Ann. N. Y. Acad. Sci. 959, 263-274 (2002).

    2. Doughan, A.K., and Dikalov, S.I. Mitochondrial redox cycling of mitoquinone leads to superoxide production and cellular apoptosis. Antioxid. Redox Signal. 9(11), 1825-1836 (2007).

    3. Huang, W., Cash, N., Wen, L., et al. Effects of the mitochondria-targeted antioxidant mitoquinone in murine acute pancreatitis. Mediators Inflamm. 2015:901780, (2015).