A mitochondria-targeted antioxidant
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Mitoquinol (mesylate)

Item No. 89950

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[10-(2,5-dihydroxy-3,4-dimethoxy-6-methylphenyl)decyl]triphenyl-phosphonium, monomethanesulfonate
CAS Number
845959-55-9
Molecular Formula
C37H46O4P • CH3O3S
Formula Weight
680.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 0.3 mg/ml
λmax
268, 275, 290 nm
SMILES
OC1=C(CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C(C)=C(O)C(OC)=C1OC.O=S(C)([O-])=O
InChi Code
InChI=1S/C37H45O4P.CH4O3S/c1-29-33(35(39)37(41-3)36(40-2)34(29)38)27-19-8-6-4-5-7-9-20-28-42(30-21-13-10-14-22-30,31-23-15-11-16-24-31)32-25-17-12-18-26-32;1-5(2,3)4/h10-18,21-26H,4-9,19-20,27-28H2,1-3H3,(H-,38,39);1H3,(H,2,3,4)
InChi Key
WPMXVYGZUOSRAN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $39

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    5 mg

    $145

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    10 mg

    $231

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    25 mg

    $434

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    Product Description

    Mitoquinol is a mitochondria-targeted antioxidant and reduced form of mitoquinone (Item No. 29317).1 It reduces hydrogen peroxide production in succinate-fueled isolated bovine aortic endothelial mitochondria.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kelso, G.F., Porteous, C.M., Coulter, C.V., et al. Selective targeting of a redox-active ubiquinone to mitochondria within cells. Antioxidant and antiapoptotic properties. The Journal of Biological Chemisty 276(7), 4588-4596 (2001).

    2. O'Malley, Y., Fink, B.D., Ross, N.C., et al. Reactive oxygen and targeted antioxidant administration in endothelial cell mitochondria. The Journal of Biological Chemisty 281(52), 39766-39775 (2006).

    Product Citations

    Soriano-Castell, D., Currais, A., and Maher, P. Defining a pharmacological inhibitor fingerprint for oxytosis/ferroptosis. Free Radic. Biol. Med. S0891-5849(21), (2021).

    Yu, C.-H., Davidson, S., Harapas, C.R., et al. TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS. Cell 183(3), 636-649 (2020).

    Bailey, C.P., Figueroa, M., Gangadharan, A., et al. Scaffolding LSD1 inhibitors impair NK cell metabolism and cytotoxic function through depletion of glutathione. Front. Immunol. 11, 2196 (2020).