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5-Aminoisotonitazene

Item No. 29318

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • ​5-Amino Isotodesnitazene
Technical Information
Formal Name
5-amino-N,N-diethyl-2-[[4-(1-methylethoxy)phenyl]methyl]-1H-benzimidazole-1-ethanamine
CAS Number
2732926-25-7
Molecular Formula
C23H32N4O
Formula Weight
380.5
Purity
≥98%
Formulation
A solution in acetonitrile
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/ml
λmax
221 nm
SMILES
NC1=CC=C2C(N=C(CC3=CC=C(OC(C)C)C=C3)N2CCN(CC)CC)=C1
InChi Code
InChI=1S/C23H32N4O/c1-5-26(6-2)13-14-27-22-12-9-19(24)16-21(22)25-23(27)15-18-7-10-20(11-8-18)28-17(3)4/h7-12,16-17H,5-6,13-15,24H2,1-4H3
InChi Key
DVCBBZBNZSSXMS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    5-Aminoisotonitazene (Item No. 29318) is an analytical reference standard categorized as an opioid.1,2 It is a metabolite of isotonitazene (Item Nos. 30880 | 27255). This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Krotulski, A.J., Papsun, D.M., Kacinko, S.L., et al. Isotonitazene quantitation and metabolite discovery in authentic forensic casework. J. Anal. Toxicol. 44(6), 521-530 (2020).

    2. Vandeputte, M.M., Van Uytfanghe, K., Layle, N.K., et al. Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of "nitazene" 2-benzylbenzimidazole synthetic opioids. ACS Chem. Neurosci. 12(7), 1241-1251 (2021).

    Product Citations

    Hardwick, E.K., and Davidson, J.T. Structural characterization of nitazene analogs using electrospray ionization-tandem mass spectrometry (ESI-MS/MS). Drug Test Anal. (2025).

    Kozell, L.B., Eshleman, A.J., Wolfrum, K.M., et al. Pharmacology of newly identified nitazene variants reveals structural determinants of affinity, potency, selectivity for mu opioid receptors. Neuropharmacology 276, 110512 (2025).

    Leonard, A.C., Lenert-Mondou, C., Chayer, R., et al. Computational design of dynamic biosensors for emerging synthetic opioids. BioRxiv (2025).

    Taoussi, O., Berardinelli, D., Zaami, S., et al. Human metabolism of four synthetic benzimidazole opioids: Isotonitazene, metonitazene, etodesnitazene, and metodesnitazene. Arch. Toxicol. (2024).

    Vandeputte, M.M., Van Uytfanghe, K., Layle, N.K., et al. Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of "nitazene" 2-benzylbenzimidazole synthetic opioids. ACS Chem. Neurosci. 12(7), 1241-1251 (2021).