A Certified Reference Material
Features
  • This product is qualified as a Certified Reference Material (CRM) that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This CRM has been characterized by metrologically valid procedures and may be used as a quantitative analytical reference standard
  • Certificate of analysis provides the certified property values and the associated uncertainties, including a statement of metrological traceability for the certified values
  • Bulk material is available for qualified institutions; please contact our sales department for pricing
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Isotonitazene (CRM)

A 1 mg/ml solution in methanol

Item No. 30880

Exempt Product (US)
Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-diethyl-2-[[4-(1-methylethoxy)phenyl]methyl]-5-nitro-1H-benzimidazole-1-ethanamine
CAS Number
14188-81-9
Molecular Formula
C23H30N4O3
Formula Weight
410.5
Formulation
A 1 mg/ml solution in methanol
SMILES
CCN(CC)CCN1C(CC2=CC=C(OC(C)C)C=C2)=NC3=CC([N+]([O-])=O)=CC=C31
InChi Code
InChI=1S/C23H30N4O3/c1-5-25(6-2)13-14-26-22-12-9-19(27(28)29)16-21(22)24-23(26)15-18-7-10-20(11-8-18)30-17(3)4/h7-12,16-17H,5-6,13-15H2,1-4H3
InChi Key
OIOQREYBGDAYGT-UHFFFAOYSA-N
Regulatory Information
DEA Exempt Notification
This product is a DEA exempt preparation of a scheduled compound - does not require DEA Controlled Substance registration or DEA 222 form. For alternate sizes please contact sales.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $154

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    Product Description

    Isotonitazene (Item No. 30880) is a certified reference material categorized as an opioid.1,2,3 Isotonitazene has analgesic effects in mice.4 It has been associated with overdoses.5 Isotonitazene is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Casy, A.F., and Wright, J. Ionisation constants and partition coefficients of some analgesically active 2-benzylbenzimidazole derivatives and related compounds. J. Pharm. Pharmacol. 18(10), 677-683 (1966).

    2. Blanckaert, P., Cannaert, A., Van Uytfanghe, K., et al. Report on a novel emerging class of highly potent benzimidazole NPS opioids: Chemical and in vitro functional characterization of isotonitazene. Drug Test. Anal. 12(4), 422-430 (2019).

    3. Vandeputte, M.M., Van Uytfanghe, K., Layle, N.K., et al. Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of "nitazene" 2-benzylbenzimidazole synthetic opioids. ACS Chem. Neurosci. 12(7), 1241-1251 (2021).

    4. Ujváry, I., Christie, R., Evans-Brown, M., et al. DARK classics in chemical neuroscience: Etonitazene and related benzimidazoles. ACS Chem. Neurosci. 12(7), 1072-1092 (2021).

    5. Shover, C.L., Falasinnu, T.O., Freedman, R.B., et al. Emerging characteristics of isotonitazene-involved overdose deaths: A case-control study. J. Addict. Med. 15(5), 429-431 (2021).

    Product Citations

    Malcolm, N.J., Palkovic, B., Sprague, D.J., et al. Mu-opioid receptor selective superagonists produce prolonged respiratory depression. iScience 26(7), 107121 (2023).

    Leonard, A.C., Lenert-Mondou, C., Chayer, R., et al. Computational design of dynamic biosensors for emerging synthetic opioids. BioRxiv (2025).