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Isotonitazene-d7

Item No. 29319

Restricted Product (Schedule I)
Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-diethyl-2-(5-nitro-2-(4-((propan-2-yl-d7)oxy)benzyl)-1H-benzo[d]imidazol-1-yl)ethan-1-amine
CAS Number
3053113-17-7
Molecular Formula
C23H23D7N4O3
Formula Weight
417.6
Purity
≥99% deuterated forms (d1-d7)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/ml
λmax
242, 310 nm
SMILES
CCN(CC)CCN1C(CC2=CC=C(OC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])C=C2)=NC3=CC([N+]([O-])=O)=CC=C31
InChi Code
InChI=1S/C23H30N4O3/c1-5-25(6-2)13-14-26-22-12-9-19(27(28)29)16-21(22)24-23(26)15-18-7-10-20(11-8-18)30-17(3)4/h7-12,16-17H,5-6,13-15H2,1-4H3/i3D3,4D3,17D
InChi Key
OIOQREYBGDAYGT-CMFMTHAFSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Isotonitazene-d7 (Item No. 29319) is intended for use as an internal standard for the quantification of isotonitazene (Item Nos. 30880 | 27255) by GC- or LC-MS. Isotonitazene is categorized as an opioid.1,2,3 Isotonitazene has analgesic effects in mice.4 It has been associated with overdoses.5 Isotonitazene is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Casy, A.F., and Wright, J. Ionisation constants and partition coefficients of some analgesically active 2-benzylbenzimidazole derivatives and related compounds. J. Pharm. Pharmacol. 18(10), 677-683 (1966).

    2. Blanckaert, P., Cannaert, A., Van Uytfanghe, K., et al. Report on a novel emerging class of highly potent benzimidazole NPS opioids: Chemical and in vitro functional characterization of isotonitazene. Drug Test. Anal. 12(4), 422-430 (2019).

    3. Vandeputte, M.M., Van Uytfanghe, K., Layle, N.K., et al. Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of "nitazene" 2-benzylbenzimidazole synthetic opioids. ACS Chem. Neurosci. 12(7), 1241-1251 (2021).

    4. Ujváry, I., Christie, R., Evans-Brown, M., et al. DARK classics in chemical neuroscience: Etonitazene and related benzimidazoles. ACS Chem. Neurosci. 12(7), 1072-1092 (2021).

    5. Shover, C.L., Falasinnu, T.O., Freedman, R.B., et al. Emerging characteristics of isotonitazene-involved overdose deaths: A case-control study. J. Addict. Med. 15(5), 429-431 (2021).

    Product Citations

    Hardwick, E.K., and Davidson, J.T. Structural characterization of nitazene analogs using electrospray ionization-tandem mass spectrometry (ESI-MS/MS). Drug Test Anal. (2025).

    Krotulski, A.J., Papsun, D.M., Walton, S.E., et al. Metonitazene in the United States-Forensic toxicology assessment of a potent new synthetic opioid using liquid chromatography mass spectrometry. Drug Test Anal. 13(10), 1697-1711 (2021).