Sporothriolide

Sporothriolide is a fungal metabolite that has been found in Sporothrix.¹ It is active against the plant pathogenic fungi U. violacea, M. microspore, and E. repens, and the alga C. fusca, but not the bacteria B. megaterium and E. coli, when used at a concentration of 10 mg/ml. Sporothriolide inhibits mycelial growth of the plant pathogenic fungus R. solani (EC₅₀ = 3.04 µg/ml) and protects against R. solani-induced rice sheath blight on rice plants when used at a concentration of 200 µg/ml.² It also prevents necrosis induced by the plant pathogenic fungus B. cinerea in pepper seedlings at 500 ppm.¹ Sporothriolide (4 mg/ml) prevents germination of L. sativum and M. sativa seedlings.

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1. Krohn, K., Ludewig, K., Aust, H.-J., et al. Biologically active metabolites from fungi. 3. sporothriolide, discosiolide, and 4-epi-ethisolide--new furofurandiones from Sporothrix sp., Discosia sp., and Pezicula livida. J. Antibiot. (Tokyo) 47(1), 113-118 (1994).

2. Cao, L.-L., Zhang, Y.-Y., Liu, Y.-J., et al. Anti-phytopathogenic activity of sporothriolide, a metabolite from endophyte Nodulisporium sp. A21 in Ginkgo biloba. Pestic. Biochem. Physiol. 129, 7-13 (2016).