A dopamine D2 receptor antagonist
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Bromopride

Item No. 29329

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide
CAS Number
4093-35-0
Synonyms
  • Emepride
  • Emoril
  • Viadil
Molecular Formula
C14H22BrN3O2
Formula Weight
344.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
BrC1=C(N)C=C(OC)C(C(NCCN(CC)CC)=O)=C1
InChi Code
InChI=1S/C14H22BrN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
InChi Key
GIYAQDDTCWHPPL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $145

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    10 mg

    $236

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    25 mg

    $502

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    Product Description

    Bromopride is a dopamine D2 receptor antagonist (Ki = 14 nM).1 It binds to bovine anterior pituitary membranes with an IC50 value of 2.13 μM.2 Bromopride inhibits cholinesterase activity in vitro in rat plasma and striatum homogenate (IC50s = 67.8 and 38.4 μM, respectively).3 It increases serum prolactin levels in rats by 100% when used at a dose of 0.02 mol/kg.2 Bromopride (2.5 mg/kg) decreases locomotion and rearing in an open field test and impairs acquistion, but not retention, of a conditioned avoidance response in a two-way active conditioned avoidance test in rats.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tonini, M., Cipollina, L., Poluzzi, E., et al. Clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics. Aliment. Pharmacol. Ther. 19(4), 379-390 (2004).

    2. Meltzer, H.Y., Simonovic, M., and So, R. Effects of a series of substituted benzamides on rat prolactin secretion and 3H-spiperone binding to bovine anterior pituitary membranes. Life Sci. 32(25), 2877-2886 (1983).

    3. Nasello, A.G., Gidali, D., de Sá-Rocha, L.C., et al. Differential effects of bromopride and domperidone on cholinesterase activity in rat tissues. Life Sci. 56(3), 151-156 (1995).

    4. Nasello, A.G., Vanzeler, M.L., and Felicio, L.F. A comparison of bromopride and domperidone effects on rat conditioned avoidance and motor activity. Pharmacol. Toxicol. 68(1), 46-50 (1991).