A thiazide diuretic
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Trichlormethiazide

Item No. 29331

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide
CAS Number
133-67-5
Molecular Formula
C8H8Cl3N3O4S2
Formula Weight
380.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5mg/mLDMSO: 20mg/mLDMSO:PBS (pH 7.2) (1:3): 0.25mg/mL
λmax
225, 267, 313 nm
SMILES
NS(C1=C(Cl)C=C(NC(C(Cl)Cl)NS2(=O)=O)C2=C1)(=O)=O
InChi Code
InChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)
InChi Key
LMJSLTNSBFUCMU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $36

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    5 g

    $120

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    10 g

    $186

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    Product Description

    Trichlormethiazide is a thiazide diuretic.1 It inhibits sodium and chloride ion flux in the connecting tubule, but not the cortical collecting duct or the distal convoluted tubule, in isolated rabbit kidney tubules when used at a concentration of 1 mM. Trichlormethiazide increases relaxation induced by acetylcholine (Item No. 23829) in norepinephrine-precontracted mesenteric arterial rings isolated from spontaneously hypertensive rats (EC50 = 33 nM).2 It increases urine output and urinary excretion of sodium, potassium, and chloride ions in dogs in a dose-dependent manner.3 It reduces systolic blood pressure in spontaneously hypertensive, but not normotensive, rats when administered at doses of 10 and 30 mg/kg.3 Formulations containing trichlormethiazide have been used in the treatment of edema and hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shimizu, T., Yoshitomi, K., Nakamura, M., et al. Site and mechanism of action of trichlormethiazide in rabbit distal nephron segments perfused in vitro. J. Clin. Invest. 82(2), 721-730 (1988).

    2. Kähönen, M., Mäkynen, H., Arvola, P., et al. Arterial function after trichlormethiazide therapy in spontaneously hypertensive rats. J. Pharmacol. Exp. Ther. 272(3), 1223-1230 (1995).

    3. Ueda, M., Matsuda, S., Tonda, K., et al. Antihypertensive effect of trichlormethiazide in spontaneously hypertensive rats. Jpn. J. Pharmacol. 28(4), 617-626 (1978).