A β2-adrenergic receptor agonist
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Terbutaline

Item No. 29337

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol
CAS Number
23031-25-6
Molecular Formula
C12H19NO3
Formula Weight
225.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly solubleWater: 100 mM
SMILES
OC1=CC(O)=CC(C(O)CNC(C)(C)C)=C1
InChi Code
InChI=1S/C12H19NO3/c1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8/h4-6,11,13-16H,7H2,1-3H3
InChi Key
XWTYSIMOBUGWOL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $49

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    50 mg

    $86

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    100 mg

    $143

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    500 mg

    $609

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    Product Description

    Terbutaline is a short-acting β2-adrenergic receptor (β2-AR) agonist and an active metabolite of bambuterol (Item No. 17887).1,2,3 It binds to β1-, β2-, and β3-ARs (Ki = 31.3, 15.4, and 79.8 nM, respectively) and selectively increases adenylyl cyclase activity in CHO cell membranes expressing recombinant human β2- or β3- over β1-ARs at concentrations 100-fold greater than the respective Ki values.1 Terbutaline inhibits histamine release induced by ovalbumin in isolated guinea pig lung mast cells.2 It also inhibits airway obstruction induced by methacholine (acetyl-β-methylcholine; Item No. 23092) or leukotriene D4 (LTD4; Item No. 20310) in anesthetized guinea pigs.4 Formulations containing terbutaline have been used in the treatment of asthma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hoffmann, C., Leitz, M.R., Oberdorf-Maass, S., et al. Comparative pharmacology of human β-adrenergic receptor subtypes—characterization of stably transfected receptors in CHO cells. N.-S. Arch. Pharmacol. 369(2), 151-159 (2004).

    2. Lau, H.Y.A., Wong, P.L., and Lai, C.K.W. Effects of β2-adrenergic agonists on isolated guinea pig lung mast cells. Agents Actions 42(3-4), 92-94 (1994).

    3. Olsson, O.A.T., and Svenson, L.-Å. New lipophilic terbutaline ester prodrugs with long effect duration. Pharm. Res. 1(1), 19-23 (1984).

    4. Salonen, R.O. Actions of bronchodilator drugs, glucocorticoid, and their combinations on airways in rats and guinea pigs. Acta. Pharmacol. Toxicol. (Copenh) 57(Suppl. 3), 1-38 (1985).