A mixture of disialogangliosides
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Disialoganglioside Mixture

Item No. 29360

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formulation
A solution in chloroform:methanol:water (2:1:0.1)
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 ml

    $283

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    Product Description

    Disialogangliosides are membrane sphingolipids that contain two sialic acid residues linked to a galactose moiety.1 They have roles in cell proliferation, immune regulation, tumor cell invasion and metastasis, intra- and intercellular signaling, and neurogenesis.1,2,3,4,5 Disialoganglioside Mixture contains the disialogangliosides GD1a (Item No. 31591), GD1b (Item No. 31708), and GD3 (Item No. 31709) and is intended for use as a reference standard for the detection of these disialogangliosides in various sample types by TLC or LC-MS. This mixture is supplied in an amber ampule in which the headspace has been purged with argon to prevent lipid oxidation. [Matreya, LLC. Catalog No. 1509]

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mukherjee, P., Faber, A.C., Shelton, L.M., et al. Thematic review series: Sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a. J. Lipid Res. 49(5), 929-938 (2008).

    2. Liang, S., Wang, M., Tapping, R.I., et al. Ganglioside GD1a is an essential coreceptor for Toll-like receptor 2 signaling in response to the B subunit of type IIb enterotoxin. The Journal of Biological Chemisty 282(10), 7532-7542 (2007).

    3. Kolter, T. Ganglioside biochemistry. ISRN Biochem. 506160 (2012).

    4. De Maria, R., Lenti, L., Malisan, F., et al. Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis. Science 277(5332), 1652-1655 (1997).

    5. Wang, J., Cheng, A., Wakade, C., et al. Ganglioside GD3 is required for neurogenesis and long-term maintenance of neural stem cells in the postnatal mouse brain. J. Neurosci. 34(41), 13790-13800 (2014).