A triterpene with diverse biological activities
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Arjunolic Acid

Item No. 29438

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2α,3β,4α)-2,3,23-trihydroxy-olean-12-en-28-oic acid
CAS Number
465-00-9
Molecular Formula
C30H48O5
Formula Weight
488.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
CC1(C)CC[C@]2(C(O)=O)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])[C@@](CO)(C)[C@@H](O)[C@H](O)C[C@]5(C)[C@@]4([H])CC=C3[C@]2([H])C1
InChi Code
InChI=1S/C30H48O5/c1-25(2)11-13-30(24(34)35)14-12-28(5)18(19(30)15-25)7-8-22-26(3)16-20(32)23(33)27(4,17-31)21(26)9-10-29(22,28)6/h7,19-23,31-33H,8-17H2,1-6H3,(H,34,35)/t19-,20+,21+,22+,23-,26-,27-,28+,29+,30-/m0/s1
InChi Key
RWNHLTKFBKYDOJ-DDHMHSPCSA-N
Origin
Plant/Cyclocarya paliurus
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $116

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    1 mg

    $220

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    5 mg

    $578

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    10 mg

    $924

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    Product Description

    Arjunolic acid is a triterpene that has been found in T. arjuna and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties.1,2,3 It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay when used at a concentration of 0.8 mM.1 Arjunolic acid (20 mg/kg for four days) prevents arsenic-induced decreases in the activity of superoxide dismutase (SOD1), catalase, GST, and glutathione reductase in mouse brain. It reduces tumor growth in an Ehrlich murine spontaneous adenocarcinoma model when administered at doses of 100 and 250 mg/kg for 20 days.2 Arjunolic acid reduces renal fibrosis and increases in kidney TNF-α and IL-1β levels induced by cisplatin (Item No. 13119) in mice when administered at doses of 100 and 250 mg/kg per day for 10 days.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sinha, M., Manna, P., and Sil, P.C. Protective effect of arjunolic acid against arsenic-induced oxidative stress in mouse brain. J. Biochem. Mol. Toxicol. 22(1), 15-26 (2008).

    2. Elsherbiny, N.M., and Al-Gayyar, M.M. Anti-tumor activity of arjunolic acid against Ehrlich Ascites Carcinoma cells in vivo and in vitro through blocking TGF-β type 1 receptor. Biomed. Pharmacother. 82, 28-34 (2016).

    3. Elsherbiny, N.M., Eladl, M.A., and Al-Gayyar, M.M. Renal protective effects of arjunolic acid in a cisplatin-induced nephrotoxicity model. Cytokine 77, 26-34 (2016).