A Pim-1 kinase inhibitor
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SMI-16a

Item No. 29456

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(4-propoxyphenyl)methylene]-2,4-thiazolidinedione
CAS Number
587852-28-6
Molecular Formula
C13H13NO3S
Formula Weight
263.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
CCCOC1=CC=C(/C=C2C(NC(S\2)=O)=O)C=C1
InChi Code
InChI=1S/C13H13NO3S/c1-2-7-17-10-5-3-9(4-6-10)8-11-12(15)14-13(16)18-11/h3-6,8H,2,7H2,1H3,(H,14,15,16)/b11-8+
InChi Key
GBWOSXZUTXXXQF-DHZHZOJOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $103

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    10 mg

    $183

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    25 mg

    $402

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    Product Description

    SMI-16a is a Pim-1 kinase inhibitor (IC50 = 63 nM).1 It is selective for Pim-1 over a panel of 60 kinases. SMI-16a (5 μM) inhibits phosphorylation of the Pim-1 target protein Bad in DU145-Pim cells and inhibits the growth of PC3, DU145, LNCaP, K562, and MV4-11 cancer cells. It induces apoptosis and cell cycle arrest at the G1 phase in DU145 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Beharry, Z., Zemskova, M., Mahajan, S., et al. Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells. Mol. Cancer Ther. 8(6), 1473-1483 (2009).