An FXR antagonist
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DY 268

Item No. 29475

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(3-methoxyphenyl)methyl]-N-[4-methyl-3-(4-morpholinylsulfonyl)phenyl]-3-(4-methylphenyl)-1H-pyrazole-4-carboxamide
CAS Number
1609564-75-1
Molecular Formula
C30H32N4O5S
Formula Weight
560.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
250 nm
SMILES
CC(C=C1)=CC=C1C2=NN(CC3=CC=CC(OC)=C3)C=C2C(NC4=CC=C(C)C(S(N5CCOCC5)(=O)=O)=C4)=O
InChi Code
InChI=1S/C30H32N4O5S/c1-21-7-10-24(11-8-21)29-27(20-33(32-29)19-23-5-4-6-26(17-23)38-3)30(35)31-25-12-9-22(2)28(18-25)40(36,37)34-13-15-39-16-14-34/h4-12,17-18,20H,13-16,19H2,1-3H3,(H,31,35)
InChi Key
KQSPAAPFKIEUGH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $203

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    25 mg

    $378

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    Product Description

    DY 268 is a farnesoid X receptor (FXR) antagonist (IC50 = 7.5 nM in a time-resolved FRET assay).1 It inhibits FXR transactivation in a cell-based assay with an IC50 value of 468 nM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yu, D.D., Lin, W., Forman, B.M., et al. Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorg. Med. Chem. 22(11), 2919-2938 (2014).