A dopamine D1 receptor antagonist
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SKF 83566 (hydrobromide)

Item No. 29480

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol, monohydrobromide
CAS Number
108179-91-5
Molecular Formula
C17H18BrNO • HBr
Formula Weight
413.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 25 mMWater: 5 mM
SMILES
OC1=C(Br)C=C(CCN(C)CC2C3=CC=CC=C3)C2=C1.Br
InChi Code
InChI=1S/C17H18BrNO.BrH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H
InChi Key
SDQJYYGODYRPBR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $106

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    25 mg

    $214

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    Product Description

    SKF 83566 is a dopamine D1 receptor antagonist.1,2,3 In vivo, SKF 83566 (0.005, 0.01, and 0.03 mg/kg) reduces dexbenzetimide- and scopolamine-induced locomotor stereotypy in rats.1 It decreases ghrelin-induced increases in novel object exploration and food intake in rats when administered at a dose of 100 µg/kg.2 SKF 83566 also reduces schedule-induced polydipsia in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fritts, M.E., Mueller, K., and Morris, L. Locomotor stereotypy produced by dexbenzetimide and scopolamine is reduced by SKF 83566, not sulpiride. Pharmacol. Biochem. Behav. 60(3), 639-644 (1998).

    2. Jacoby, S.M., and Currie, P.J. SKF 83566 attenuates the effects of ghrelin on performance in the object location memory task. Neurosci. Lett. 504(3), 316-320 (2011).

    3. Mittleman, G., Rosner, A.L., and Schaub, C.L. Polydipsia and dopamine: Behavioral effects of dopamine D1 and D2 receptor agonists and antagonists. J. Pharmacol. Exp. Ther. 271(2), 638-650 (1994).