An inhibitor of NGF-p75 NGFR interactions
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PD 90780 (hydrate)

Item No. 29488

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-(benzoylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid, hydrate
Molecular Formula
C19H14N4O4 • XH2O
Formula Weight
362.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 36 mg/ml
λmax
236, 287, 312 nm
SMILES
O=C(NC1=CC=C(N(C)C2=CC(C(O)=O)=NN2C3=O)C3=C1)C4=CC=CC=C4.O
InChi Code
InChI=1S/C19H14N4O4.H2O/c1-22-15-8-7-12(20-17(24)11-5-3-2-4-6-11)9-13(15)18(25)23-16(22)10-14(21-23)19(26)27;/h2-10H,1H3,(H,20,24)(H,26,27);1H2
InChi Key
CPXCLWYHBRAPEA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

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    10 mg

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    Product Description

    PD 90780 is an inhibitor of the interaction between NGF and the p75 NGF receptor (NGFR).1 It binds to NGF (KD = 25.83 μM) and inhibits NGF binding to the extracellular domain of p75 NGFR (IC50 = 220 nM), as well as to Q1-CHO cells expressing full-length human p75 NGFR (IC50 = 300 nM).1,2 PD 90780 inhibits NGF-dependent differentiation of PC12 cells (IC50 = 33.22 μM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Spiegel, K., Agrafiotis, D., Caprathe, B., et al. PD 90780, a non peptide inhibitor of nerve growth factor’s binding to the P75 NGF receptor. Biochem. Biophys. Res. Commun. 217(2), 488-494 (1995).

    2. Kennedy, A.E., Laamanen, C.A., Ross, M.S., et al. Nerve growth factor inhibitor with novel-binding domain demonstrates nanomolar efficacy in both cell-based and cell-free assay systems. Pharmacol. Res. Perspect. 5(5), e00339 (2017).