An AT2 receptor antagonist
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Tasosartan

Item No. 29495

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,8-dihydro-2,4-dimethyl-8-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-pyrido[2,3-d]pyrimidin-7(6H)-one
CAS Number
145733-36-4
Synonyms
  • WAY-ANA-756
Molecular Formula
C23H21N7O
Formula Weight
411.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 14 mg/mlEthanol: 2 mg/ml
λmax
251 nm
SMILES
CC1=NC(C)=C(CCC(N2CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3)=O)C2=N1
InChi Code
InChI=1S/C23H21N7O/c1-14-18-11-12-21(31)30(23(18)25-15(2)24-14)13-16-7-9-17(10-8-16)19-5-3-4-6-20(19)22-26-28-29-27-22/h3-10H,11-13H2,1-2H3,(H,26,27,28,29)
InChi Key
ADXGNEYLLLSOAR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $103

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    50 mg

    $183

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    100 mg

    $322

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    250 mg

    $753

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    Product Description

    Tasosartan is an angiotensin II type 2 (AT2) receptor antagonist (IC50 = 1.2 nM in rat adrenal gland membranes).1 It also binds to the AT1 receptor (Ki = 46.6 nM in rat liver epithelial cells).2 Tasosartan (3 mg/kg, intraduodenally) reduces the AT2-induced pressor response in rats.3 It also decreases mean arterial pressure in a rat model of hypertension induced by renal artery constriction when administered intragastrically or intravenously at doses of 1 and 3 mg/kg.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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