An anti-allergic DHEA derivative
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pNPS-DHA

Item No. 29507

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4Z,7Z,10Z,13Z,16Z,19Z)-N-[(4-nitrophenyl)sulfonyl]docosa-4,7,10,13,16,19-docosahexaenamide
CAS Number
2454246-25-2
Synonyms
  • CAY10741
  • Compound 59
  • DHA-nitrophenyl sulfonamide
  • p-Nitrophenyl sulfonamide Docosahexaenoic Acid
Molecular Formula
C28H36N2O5S
Formula Weight
512.7
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Methyl Acetate: Soluble
λmax
256 nm
SMILES
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(NS(C1=CC=C([N+]([O-])=O)C=C1)(=O)=O)=O
InChi Code
InChI=1S/C28H36N2O5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-28(31)29-36(34,35)27-24-22-26(23-25-27)30(32)33/h3-4,6-7,9-10,12-13,15-16,18-19,22-25H,2,5,8,11,14,17,20-21H2,1H3,(H,29,31)/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-
InChi Key
VDIWFKLOBZZOII-KUBAVDMBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $186

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    25 mg

    $420

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    Product Description

    pNPS-DHA is an arylamide derivative of docosahexaenoyl ethanolamide (DHEA; Item No. 10007534) that has anti-allergic activity.1 It inhibits degranulation of RBL-2H3 mast cells (IC50 = 15 µM). pNPS-DHA (1,000 mg/kg) inhibits IgE-dependent passive cutaneous anaphylaxis (PCA) in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, I.-H., Kanayama, Y., Nishiwaki, H., et al. Structure-activity relationships of fish oil derivatives with anti-allergic activity in vitro and in vivo. J. Med. Chem. 62(21), 9576-9592 (2019).