An inhibitor of αvβ3 integrin
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Alternative(s)
44991Cyclo(RGDfK) (trifluoroacetate salt)
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Cyclo(RGDfK)

Item No. 29514

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-lysyl)
CAS Number
161552-03-0
Synonyms
  • Cyclo(Arg-Gly-Asp-D-Phe-Lys)
Molecular Formula
C27H41N9O7
Formula Weight
603.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 15 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
NC(NCCC[C@@H](C(NCC(N[C@H]1CC(O)=O)=O)=O)NC([C@H](CCCCN)NC([C@@H](CC2=CC=CC=C2)NC1=O)=O)=O)=N
InChi Code
InChI=1S/C27H41N9O7/c28-11-5-4-9-18-24(41)34-17(10-6-12-31-27(29)30)23(40)32-15-21(37)33-20(14-22(38)39)26(43)36-19(25(42)35-18)13-16-7-2-1-3-8-16/h1-3,7-8,17-20H,4-6,9-15,28H2,(H,32,40)(H,33,37)(H,34,41)(H,35,42)(H,36,43)(H,38,39)(H4,29,30,31)/t17-,18-,19+,20-/m0/s1
InChi Key
NVHPXYIRNJFKTE-HAGHYFMRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    100 mg

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    Cayman Chemical
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    Product Description

    Cyclo(RGDfK) is a synthetic lipopeptide inhibitor of αvβ3 integrin (IC50 = 1.33 nM).1 Osteoblast cultures, which express αvβ5 and αvβ3 integrins, but not M21L cells that do not express these integrins, bind to cyclo(RGDfK)-coated surfaces. Cyclo(RGDfK) is taken up into tumors in vivo and in vitro and it has been polymerized or conjugated to various fluorophores, radiolabels, and peptide sequences for use in fluorescent and PET imaging to study tumor cell adhesion.2,3,1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Šimeček, J., Notni, J., Kapp, T.G., et al. Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of 68Ga-NOPO-c(RGDfK). Mol. Pharm. 11(5), 1687-1695 (2014).

    2. Dijkgraaf, I., Beer, A.J., and Wester, H.-J. Application of RGD-containing peptides as imaging probes for alphavbeta3 expression. Front. Biosci. (Landmark Ed.) 14(3), 887-899 (2009).

    3. Janssen, M., Oyen, W.J.G., Massuger, L.F.A.G., et al. Comparison of a monomeric and dimeric radiolabeled RGD-peptide for tumor targeting. Cancer Biother. Radiopharm. 17(6), 641-646 (2002).