A bile acid
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Cholenic Acid

Item No. 29543

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3β-hydroxy-chol-5-en-24-oic acid
CAS Number
5255-17-4
Synonyms
  • 3β-hydroxy-5-Cholenic Acid
Molecular Formula
C24H38O3
Formula Weight
374.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS (pH 7.2) (1:4): 0.25 mg/ml
SMILES
C[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
InChi Code
InChI=1S/C24H38O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h5,15,17-21,25H,4,6-14H2,1-3H3,(H,26,27)/t15-,17+,18+,19-,20+,21+,23+,24-/m1/s1
InChi Key
HIAJCGFYHIANNA-QIZZZRFXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

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    250 mg

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    500 mg

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    1 g

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    Product Description

    Cholenic acid is a monohydroxy bile acid.1 It is a cholesterol oxidation product formed by 7α-hydroxylation of 27-hydroxycholesterol (Item Nos. 14790 | 14791), as well as a precursor in the biosynthesis of chenodeoxycholic acid (Item No. 10011286). Levels of cholenic acid are increased in patients with neonatal liver disease harboring mutations in CYP7A1, the gene encoding 7α-hydroxylase, as well as in patients with intrahepatic and extrahepatic cholestasis.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, C., Martin, K.O., and Javitt, N.B. Bile acid synthesis: 7α-Hydroxylation of intermediates in the sterol 27-hydroxylase metabolic pathway. J. Lipid. Res. 37(6), 1356-1362 (2006).

    2. Setchell, K.D.R., Schwarz, M., O'Connell, N.C., et al. Identification of a new inborn error in bile acid synthesis: Mutation of the oxysterol 7α-hydroxylase gene causes severe neonatal liver disease. J. Clin. Invest. 102(9), 1690-1703 (1998).

    3. Sugiyama, K., Okuyama, S., Imoto, M., et al. Clinical evaluation of serum 3β-hydroxy-5-cholenoic acid in hepatobiliary disease. Gastroenterologia Japonica 21(6), 608-616 (1986).