β2-Microglobulin (dog, recombinant)

β2-Microglobulin is a 98-amino acid protein and the light chain component of major histocompatibility complex (MHC) class I molecules.^1,2 It is non-covalently associated with the MHC class I α chain and comprises a protein-building subunit of the MHC class I molecule to facilitate complex transport to the cell surface and antigen presentation to cytotoxic T cells. β2-Microglobulin is found in all nucleated cells, as well as in extracellular fluids, including urine and serum, and MHC class I-associated β2-microglobulin exhibits dissociation and equilibrium exchange with circulating soluble β2-microglobulin.^1,3 Germline mutations at the β2-microglobulin exon 1/intron 1 splice site have been found in dog mammary gland simple and complex carcinoma tumor samples.⁴

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1. Nomura, T., Huang, W.-C., Zhau, H.E., et al. β₂-Microglobulin-mediated signaling as a target for cancer therapy. Anticancer Agents Med. Chem. 14(3), 343-352 (2014).

2. Nakajima, Y., Hoshi, F., Higuchi, S., et al. The complete amino acid sequence of dog β₂-microglobulin. J. Vet. Med. Sci. 61(5), 517-521 (1999).

3. Nakajima, Y., Hoshi, F., Higuchi, S., et al. Determination of canine β₂-microgloblin in plasma and urine by enzyme-linked immunosorbent assay. J. Vet. Med. Sci. 63(3), 343-345 (2001).

4. Tanaka, T., Shimada, T., Akiyoshi, H., et al. Germline polymorphism at the β₂-microglobulin exon 1/intron 1 splice site in canine mammary gland simple and complex carcinomas. Vet. Rec. 172(20), 529 (2013).