A prodrug form of EIDD-1931
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Active Metabolite(s)
9002958EIDD-1931
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Molnupiravir

Item No. 29586

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
uridine, 4Z-oxime, 5′-(2-methylpropanoate)
CAS Number
2492423-29-5
Synonyms
  • EIDD-2801
  • β-D-N4-Hydroxycytidine-5′-isopropyl ester
  • MK-4482
Molecular Formula
C13H19N3O7
Formula Weight
329.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
235, 276 nm
SMILES
O=C(N/1)N([C@H]2[C@H](O)[C@H](O)[C@@H](COC(C(C)C)=O)O2)C=CC1=N/O
InChi Code
InChI=1S/C13H19N3O7/c1-6(2)12(19)22-5-7-9(17)10(18)11(23-7)16-4-3-8(15-21)14-13(16)20/h3-4,6-7,9-11,17-18,21H,5H2,1-2H3,(H,14,15,20)/t7-,9-,10-,11-/m1/s1
InChi Key
HTNPEHXGEKVIHG-QCNRFFRDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    Molnupiravir is a prodrug form of the antiviral ribonucleoside analog EIDD-1931 (Item No. 9002958).1,2 Molnupiravir (500 mg/kg) reduces body weight loss, lung hemorrhage, and lung viral titers, as well as improves pulmonary function in mouse models of severe acute respiratory syndrome coronavirus (SARS-CoV) or Middle East respiratory syndrome coronavirus (MERS-CoV) infection when administered prophylactically at 2 hours pre-infection or therapeutically at 12 hours post-infection.1 It also reduces shed virus load and fever in ferret models of H1N1 or H3N2 influenza A virus infection when administered at a dose of 100 mg/kg twice per day.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sheahan, T.P., Sims, A.C., Zhou, S., et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci. Transl. Med. 12(541), eabb5883 (2020).

    2. Toots, M., Yoon, J.-J., Cox, R.M., et al. Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci. Transl. Med. 11(515), eaax5866 (2019).