A ribonucleoside analog with antiviral activity
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EIDD-1931

Item No. 9002958

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
uridine, 4-oxime
CAS Number
3258-02-4
Synonyms
  • β-D-N4-Hydroxycytidine
  • N4-Hydroxycytidine
Molecular Formula
C9H13N3O6
Formula Weight
259.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
235, 275 nm
SMILES
O[C@@H]1[C@@H](CO)O[C@](N2C(N=C(NO)C=C2)=O)([H])[C@@H]1O
InChi Code
InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6-,7-,8-/m1/s1
InChi Key
XCUAIINAJCDIPM-XVFCMESISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    EIDD-1931 is a ribonucleoside analog with antiviral activity.1,2,3,4 It inhibits replication of severe acute respiratory syndrome coronavirus (SARS-CoV) in Vero 76 cells, Middle East respiratory syndrome coronavirus (MERS-CoV) in Calu-3 2B4 cells, and SARS-CoV-2 in Vero cells (IC50s =0.1, 0.15 and 0.3 μM, respectively).3,4 It also reduces viral titers of Venezuelan equine encephalitis virus (VEEV) TC-83 in infected Vero cells (EC50 = 0.426 μM) and wild-type and remdesivir-resistant strains of the model CoV mouse hepatitis virus (MHV) in infected DBT cells.2,4 EIDD-1931 (100 and 400 mg/kg twice per day) reduces lung viral titers in mouse models of respiratory syncytial virus (RSV) and H1N1 influenza A virus infection.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yoon, J.-J., Toots, M., Lee, S., et al. Orally efficacious broad-spectrum ribonucleoside analog inhibitor of influenza and respiratory syncytial viruses. Antimicrob. Agents Chemother. 62(8), e00766-00718 (2018).

    2. Urakova, N., Kuznetsova, V., Crossman, D.K., et al. β-ᴅ-N4-Hydroxycytidine Is a potent anti-alphavirus compound that induces a high level of mutations in the viral genome. J. Virol. 92(3), e01965-01917 (2018).

    3. Barnard, D.L., Day, C.W., Bailey, K., et al. Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice. Antivir. Chem. Chemother. 17(5), 275-784 (2006).

    4. Sheahan, T.P., Sims, A.C., Zhou, S., et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci. Transl. Med. 12(541), eabb5883 (2020).