An alkaloid with diverse biological activities
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Sophocarpine

Item No. 29598

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(7aS,13aR,13bR,13cS)-2,3,6,7,7a,8,13,13a,13b,13c-decahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one
CAS Number
6483-15-4
Synonyms
  • 13,14-Dehydromatrine
Molecular Formula
C15H22N2O
Formula Weight
246.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 2 mg/mlEthanol: 1 mg/ml *
SMILES
O=C1C=CC[C@@]2([H])N1C[C@@]3([H])[C@@]4([H])[C@]2([H])CCCN4CCC3
InChi Code
InChI=1S/C15H22N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h1,7,11-13,15H,2-6,8-10H2/t11-,12+,13+,15-/m0/s1
InChi Key
AAGFPTSOPGCENQ-JLNYLFASSA-N
Origin
Plant/Macleaya cordata (Willd.) R. Br.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    100 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Sophocarpine is an alkaloid that has been found in S. flavescens roots and has diverse biological activities.1,2,3,4,5 It is cytotoxic to HL-60, U937, K562, EC109, A549, and HepG2 cancer cells (IC50s = 1.64-12.86 mM).1 Sophocarpine is nematocidal against B. xylophilus in vitro.2 In vivo, sophocarpine (30 mg/kg) reduces infarct size, cardiac muscle fiber swelling and hypertrophy, and neutrophil infiltration in a rat model of myocardial ischemia and reperfusion injury.3 It decreases liver weight, fibrosis, and levels of IL-6, TNF-α, and TGF-β1 in a rat model of non-alcoholic steatohepatitis (NASH).4 Sophocarpine (15 and 30 mg/kg) reduces carrageenan-induced hind paw edema in rats and decreases acetic acid-induced writhing in mice.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lin, Z., Huang, C.-F., Liu, X.-S., et al. In vitro anti-tumour activities of quinolizidine alkaloids derived from Sophora flavescens Ait. Basic Clin. Pharmacol. Toxicol. 108(5), 304-309 (2011).

    2. Matsuda, K., Yamada, K., Kimura, M., et al. Nematicidal activity of matrine and its derivatives against pine wood nematodes. J. Agric. Food Chem. 39(1), 189-191 (1991).

    3. Li, C., Gao, Y., Tian, J., et al. Sophocarpine administration preserves myocardial function from ischemia-reperfusion in rats via NF-κB inactivation. J. Ethnopharmacol. 135(3), 620-625 (2011).

    4. C.-Y., S., Zeng, X., Chen, S.-W., et al. Sophocarpine alleviates non-alcoholic steatohepatitis in rats. J. Gastroenterol. Hepatol. 26(4), 765-774 (2011).

    5. Gao, Y., Li, G., Li, C., et al. Anti-nociceptive and anti-inflammatory activity of sophocarpine. J. Ethnopharmacol. 125(2), 324-329 (2009).