An NSAID
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Active Metabolite(s)
70270Indomethacin
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Acemetacin

Item No. 29615

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid, carboxymethyl ester
CAS Number
53164-05-9
Molecular Formula
C21H18ClNO6
Formula Weight
415.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 3 mg/mlPBS (pH 7.2): 0.5 mg/ml
SMILES
CC1=C(CC(OCC(O)=O)=O)C2=C(C=CC(OC)=C2)N1C(C3=CC=C(Cl)C=C3)=O
InChi Code
InChI=1S/C21H18ClNO6/c1-12-16(10-20(26)29-11-19(24)25)17-9-15(28-2)7-8-18(17)23(12)21(27)13-3-5-14(22)6-4-13/h3-9H,10-11H2,1-2H3,(H,24,25)
InChi Key
FSQKKOOTNAMONP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $41

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    5 g

    $108

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    10 g

    $178

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    Product Description

    Acemetacin is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of indomethacin (Item No. 70270).1 It reduces zymosan-induced thromboxane B2 (TXB2; Item No. 19030) and prostaglandin E2 (PGE2; Item No. 14010) production in isolated rat whole blood and stomach, respectively, when administered at doses ranging from 2.7 to 83.8 µmol/kg. Acemetacin (1.3, 2.5, and 10 mg/kg) also reduces carrageenan-induced PGE2 production in rat synovial membranes.2 It decreases leukocyte infiltration in the exudate in a rat model of zymosan-induced air pouch inflammation when administered at doses of 27.9 and 83.8 µmol/kg.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chávez-Piña, A.E., McKnight, W., Dicay, M., et al. Mechanisms underlying the anti-inflammatory activity and gastric safety of acemetacin. Br. J. Pharmacol. 152(6), 930-938 (2007).

    2. Wada, Y., Nakamura, M., Kogo, H., et al. Inhibitory effect of acemetacin, a prodrug of indomethacin, on prostaglandin E2 release from inflamed synovial tissue. Jpn. J. Pharmacol. 34(4), 468-470 (1984).