A monolignal conjugate with diverse biological activities
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Isomer(s)
19577Sauchinone
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Coniferyl Ferulate

Item No. 29620

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-yl ester
CAS Number
63644-62-2
Molecular Formula
C20H20O6
Formula Weight
356.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 3 mg/ml
λmax
212, 271, 319 nm
SMILES
COC1=C(O)C=CC(/C=C/C(OC/C=C/C2=CC=C(O)C(OC)=C2)=O)=C1
InChi Code
InChI=1S/C20H20O6/c1-24-18-12-14(5-8-16(18)21)4-3-11-26-20(23)10-7-15-6-9-17(22)19(13-15)25-2/h3-10,12-13,21-22H,11H2,1-2H3/b4-3+,10-7+
InChi Key
PGLIMMMHQDNVRS-YZQQHVNFSA-N
Origin
Plant/Angelica sinensis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $72

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    5 mg

    $215

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    10 mg

    $358

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    25 mg

    $805

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    Cayman Chemical
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    Product Description

    Coniferyl ferulate is a monolignol conjugate that has been found in A. sinensis and has diverse biological activities, including antibacterial, antioxidant, enzyme inhibitory, and neuroprotective properties.1,2,3,4 It is active against the Gram-positive bacteria B. subtilis and S. aureus.2 Coniferyl ferulate scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals (EC50 = 3.6 µg/ml) and inhibits glutathione S-transferase (GST; IC50 = 0.3 µM for the human placental enzyme) in cell-free assays.3,4 Coniferyl ferulate (10 and 50 µg/ml) reduces cytotoxicity induced by amyloid-β (1-40) (Aβ40) in PC12 cells.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Grabber, J.H., Schatz, P.F., Kim, H., et al. Identifying new lignin bioengineering targets: 1. Monolignol-substitute impacts on lignin formation and cell wall fermentability. BMC Plant Biol. 10, 114 (2010).

    2. Chou, S.-H., Everngam, M.C., Sturtz, G., et al. Antibacterial activity of components from Lomatium californicum. Phytother. Res. 20(2), 153-156 (2006).

    3. Ho, C.C., Kumaran, A., and Hwang, L.S. Bio-assay guided isolation and identification of anti-Alzheimer active compounds from the root of Angelica sinensis. Food Chem. 114(1), 246-252 (2009).

    4. Chen, C., Wu, C., Lu, X., et al. Coniferyl ferulate, a strong inhibitor of glutathione S-transferase isolated from Radix Angelicae sinensis, reverses multidrug resistance and downregulates P-glycoprotein. Evid. Based Complement. Alternat. Med. 639083 (2013).