A derivative of glutathione
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S-Acetyl-L-glutathione

Item No. 29624

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-γ-glutamyl-S-acetyl-L-cysteinyl-glycine
CAS Number
3054-47-5
Synonyms
  • S-Acetylglutathione
Molecular Formula
C12H19N3O7S
Formula Weight
349.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/ml
SMILES
OC([C@@H](N)CCC(N[C@@H](CSC(C)=O)C(NCC(O)=O)=O)=O)=O
InChi Code
InChI=1S/C12H19N3O7S/c1-6(16)23-5-8(11(20)14-4-10(18)19)15-9(17)3-2-7(13)12(21)22/h7-8H,2-5,13H2,1H3,(H,14,20)(H,15,17)(H,18,19)(H,21,22)/t7-,8-/m0/s1
InChi Key
FVRWSIPJNWXCEO-YUMQZZPRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

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    Product Description

    S-Acetyl-L-glutathione is a derivative of glutathione (GSH; Item No. 10007461).1 It is more stable in plasma than GSH and, unlike GSH, can be taken up into cells, where it is converted to GSH by intracellular thioesterases.1,2,3 S-Acetyl-L-glutathione (50 μM) increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency.1 It induces apoptosis in Daudi, Raji, and Jurkat lymphoma cells when used at a concentration of 5 mM.4 It inhibits the replication of herpes simplex virus 1 (HSV-1) in human foreskin fibroblasts when used at concentrations of 5 and 10 mM.2 S-Acetyl-L-glutathione (6.25 μg/g per day), but not GSH, increases survival in a mouse model of HSV-1 infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Okun, J.G., Sauer, S., Bähr, S., et al. S-Acetylglutathione normalizes intracellular glutathione content in cultured fibroblasts from patients with glutathione synthetase deficiency. J. Inherit. Metab. Dis. 27(6), 783-786 (2004).

    2. Vogel, J.-U., Cinatl, J., Dauletbaev, N., et al. Effects of S-acetylglutathione in cell and animal model of herpes simplex virus type 1 infection. Med. Microbiol. Immunol. 194(1-2), 55-59 (2005).

    3. Galzigna, L., Rizzoli, V., Schiappelli, P., et al. S-acetyl- and S-phenylacetyl-glutathione as glutathione precursors in rat plasma and tissue preparations. Enzyme Protein 48(2), 98-104 (1994).

    4. Locigno, R., Pincemail, J., Henno, A., et al. S-acetyl-glutathione selectively induces apoptosis in human lymphoma cells through a GSH-independent mechanism. Int. J. Oncol. 20(1), 69-75 (2002).