A dual P2X3 and P2X2/3 receptor antagonist
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RO-3

Item No. 29635

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[4,5-dimethoxy-2-(1-methylethyl)phenyl]methyl]-2,4-pyrimidinediamine
CAS Number
1026582-88-6
Molecular Formula
C16H22N4O2
Formula Weight
302.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 12 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 0.2 mg/ml
SMILES
CC(C)C1=CC(OC)=C(OC)C=C1CC2=CN=C(N)N=C2N
InChi Code
InChI=1S/C16H22N4O2/c1-9(2)12-7-14(22-4)13(21-3)6-10(12)5-11-8-19-16(18)20-15(11)17/h6-9H,5H2,1-4H3,(H4,17,18,19,20)
InChi Key
PYNPWUIBJMVRIG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $168

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    25 mg

    $392

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    50 mg

    $696

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    Product Description

    RO-3 is a dual antagonist of the purinergic receptor subtypes P2X3 and P2X2/3 (IC50s = 0.1 and 1.26 μM, respectively).1 It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 receptors (IC50s = >10 μM for all) but is an antagonist of ML1-type melatonin receptors (IC50 = 0.398 μM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ford, A.P.D.W., Gever, J.R., Nunn, P.A., et al. Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br. J. Pharmacol. 147(Suppl. 2), S132-S143 (2006).