A histamine H1 receptor antagonist
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Bromodiphenhydramine (hydrochloride)

Item No. 29636

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(4-bromophenyl)phenylmethoxy]-N,N-dimethyl-ethanamine, monohydrochloride
CAS Number
1808-12-4
Synonyms
  • Bromazine
  • NSC 36113
Molecular Formula
C17H20BrNO • HCl
Formula Weight
370.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
229 nm
SMILES
CN(C)CCOC(C1=CC=C(Br)C=C1)C2=CC=CC=C2.Cl
InChi Code
InChI=1S/C17H20BrNO.ClH/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15;/h3-11,17H,12-13H2,1-2H3;1H
InChi Key
ZQDJSWUEGOYDGT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    Bromodiphenhydramine is a histamine H1 receptor antagonist.1 It induces histamine release in isolated guinea pig lung when used at a concentration of 1 mM but completely prevents ovalbumin-induced histamine release in lungs isolated from ovalbumin-sensitized guinea pigs when used at concentrations of 100 and 200 µg/ml.2 Bromodiphenhydramine (17 mg/kg) inhibits formalin-induced paw edema in rats.1 It increases survival in a mouse model of systemic S. typhimurium infection when administered at doses of 1.5 and 3 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ahmadi, A., Khalili, M., Nafarie, A., et al. Synthesis and anti-inflammatory effects of new piperazine and ethanolamine derivatives of H1-antihistaminic drugs. Mini Rev. Med. Chem. 12(12), 1282-1292 (2012).

    2. Mota, I., and Da Silva, W.D. The anti-anaphylactic and histamine-releasing properties of the antihistamines. Their effect on the mast cells. Br. J. Pharmacol. Chemother. 15(3), 396-404 (1960).

    3. Dastidar, S.G., Saha, P.K., Sanyamat, B., et al. Antibacterial activity of ambodryl and benadryl. J. Appl. Bacteriol. 41(2), 209-214 (1976).