An agonist of 5-HT7 receptors
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LP-211

Item No. 29659

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[1,1′-biphenyl]-2-yl-N-[(4-cyanophenyl)methyl]-1-piperazinehexanamide
CAS Number
1052147-86-0
Molecular Formula
C30H34N4O
Formula Weight
466.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=C(NCC1=CC=C(C#N)C=C1)CCCCCN(CC2)CCN2C3=CC=CC=C3C4=CC=CC=C4
InChi Code
InChI=1S/C30H34N4O/c31-23-25-14-16-26(17-15-25)24-32-30(35)13-5-2-8-18-33-19-21-34(22-20-33)29-12-7-6-11-28(29)27-9-3-1-4-10-27/h1,3-4,6-7,9-12,14-17H,2,5,8,13,18-22,24H2,(H,32,35)
InChi Key
BQEDZLDNNBDKDS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $36

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    10 mg

    $63

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    25 mg

    $145

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    50 mg

    $268

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    Product Description

    LP-211 is an agonist of the serotonin (5-HT) receptor subtype 5-HT7 (Ki = 0.58 nM).1 It is selective for 5-HT7 over 5-HT1A and dopamine D2 receptors (Kis = 188 and 142 nM, respectively). It induces relaxation of isolated guinea pig ileum precontracted by substance P (Item No. 24035; EC50 = 0.6 μM). LP-211 (100 nM) stimulates neurite outgrowth in primary murine striatal and cortical neurons.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Leopoldo, M., Lacivita, E., De Giorgio, P., et al. Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: Influence on lipophilicity and 5-HT7 receptor activity. Part III. J. Med. Chem. 51(18), 5813-5822 (2008).

    2. Lacivita, E., Podlewska, S., Speranza, L., et al. Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. Eur. J. Med. Chem. 120, 363-379 (2016).