A SIRT3 inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

3-TYP

Item No. 29660

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(1H-1,2,3-triazol-5-yl)-pyridine
CAS Number
120241-79-4
Molecular Formula
C7H6N4
Formula Weight
146.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:5): 0.16 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/ml
λmax
245 nm
SMILES
C1(C2=CN=CC=C2)=CN=NN1
InChi Code
InChI=1S/C7H6N4/c1-2-6(4-8-3-1)7-5-9-11-10-7/h1-5H,(H,9,10,11)
InChi Key
VYXFEFOIYPNBFK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 mg

    $75

    Add

    250 mg

    $130

    Add

    500 mg

    $241

    Add

    1 g

    $442

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    3-TYP is a sirtuin 3 (SIRT3) inhibitor (IC50 = 38 μM).1 It is selective for SIRT3 over SIRT1 and SIRT2 at 1 mM. 3-TYP (1 mM) increases acetylation of lysine residues in mitochondrial proteins in HeLa cells. It inhibits the growth of CCRF-CEM, COLO 205, OVCAR-4, OVCAR-8, and SKOV3 cells by greater than 50% when used at a concentration of 10 μM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Galli, U., Mesenzani, O., Coppo, C., et al. Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2. Eur. J. Med. Chem. 55, 58-66 (2012).