A SIRT3 inhibitor
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11076Epigenetics Screening Library (96-Well)
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3-TYP

Item No. 29660

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(1H-1,2,3-triazol-5-yl)-pyridine
CAS Number
120241-79-4
Molecular Formula
C7H6N4
Formula Weight
146.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:5): 0.16 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/ml
λmax
245 nm
SMILES
C1(C2=CN=CC=C2)=CN=NN1
InChi Code
InChI=1S/C7H6N4/c1-2-6(4-8-3-1)7-5-9-11-10-7/h1-5H,(H,9,10,11)
InChi Key
VYXFEFOIYPNBFK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    3-TYP is a sirtuin 3 (SIRT3) inhibitor (IC50 = 38 μM).1 It is selective for SIRT3 over SIRT1 and SIRT2 at 1 mM. 3-TYP (1 mM) increases acetylation of lysine residues in mitochondrial proteins in HeLa cells. It inhibits the growth of CCRF-CEM, COLO 205, OVCAR-4, OVCAR-8, and SKOV3 cells by greater than 50% when used at a concentration of 10 μM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Galli, U., Mesenzani, O., Coppo, C., et al. Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2. Eur. J. Med. Chem. 55, 58-66 (2012).