An AMPK activator
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MK-3903

Item No. 29661

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(5-[1,1′-biphenyl]-4-yl-6-chloro-1H-benzimidazol-2-yl)oxy]-2-methyl-benzoic acid
CAS Number
1219737-12-8
Molecular Formula
C27H19ClN2O3
Formula Weight
454.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10mg/mLDMSO: 15mg/mLDMSO:PBS (pH 7.2) (1:2): 0.3mg/mLEthanol: 0.2mg/mL
λmax
247, 279 nm
SMILES
ClC(C=C(N=C(OC1=CC=C(C)C(C(O)=O)=C1)N2)C2=C3)=C3C(C=C4)=CC=C4C5=CC=CC=C5
InChi Code
InChI=1S/C27H19ClN2O3/c1-16-7-12-20(13-21(16)26(31)32)33-27-29-24-14-22(23(28)15-25(24)30-27)19-10-8-18(9-11-19)17-5-3-2-4-6-17/h2-15H,1H3,(H,29,30)(H,31,32)
InChi Key
FIKQZQDYGXAUHC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $185

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    10 mg

    $341

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    25 mg

    $588

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    MK-3903 is an activator of AMP-activated protein kinase (AMPK; EC50 = 9 nM).1 It is selective for AMPK over a kinase panel at 10 µM, as well as the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2D6 (IC50s = >50 µM for both) and the pregnane X receptor (PXR; EC50 = >30 µM). MK-3903 (30 mg/kg) increases muscle and liver levels of phosphorylated ACC, an AMPK substrate, and reduces insulin resistance in diet-induced obese (DIO) mice. It inhibits hepatic fatty acid synthesis in db/db mice when administered at doses ranging from 3 to 30 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lan, P., Romero, F.A., Wodka, D., et al. Hit-to-lead optimization and discovery of 5-((5-([1,1'-biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic acid (MK-3903): A novel class of benzimidazole-based activators of AMP-activated protein kinase. J. Med. Chem. 60(21), 9040-9052 (2017).