A CCR3 antagonist
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SB-328437

Item No. 29677

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(1-naphthalenylcarbonyl)-4-nitro-L-phenylalanine, methyl ester
CAS Number
247580-43-4
Molecular Formula
C21H18N2O5
Formula Weight
378.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mM
λmax
221, 278 nm
SMILES
O=C(N[C@@H](CC1=CC=C([N+]([O-])=O)C=C1)C(OC)=O)C2=C(C=CC=C3)C3=CC=C2
InChi Code
InChI=1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1
InChi Key
VMFGCGRAIBLAFY-IBGZPJMESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    SB-328437 is a nonpeptide chemokine (C-C motif) receptor 3 (CCR3) antagonist (IC50 = 4.5 nM in a radioligand binding assay).1 It is selective for CCR3 over chemokine (C-X-C motif) receptor 1 (CXCR1), CXCR2, CCR7, complement 3a receptor (C3aR), and C5aR (IC50s = >27, >27, >33, >10, and >10 µM, respectively). SB-328437 (3.3-1,000 nM) inhibits calcium mobilization induced by chemokine (C-C motif) ligand 11 (CCL11), CCL24, and CCL13 in RBL-2H3-CCR3 cells and eosinophils. In vivo, SB-328437 reduces pulmonary Ccr3 mRNA expression, the number of eosinophils and monocytes in bronchoalveolar lavage fluid (BALF), and pulmonary IL-4 and TNF-α levels in a mouse model of asthma.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. White, J.R., Lee, J.M., Dede, K., et al. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. The Journal of Biological Chemisty 275(47), 36626-36631 (2000).

    2. Wang, T., Zhang, J.-Y., Wang, X.-D., et al. Effects of CCR3(chemokine receptor-3) on Muc5ac in airway of asthmatic mice. Zhongguo Mianyixue Zazhi 31(8), 1019-1023 (2015).