A glycoside with diverse biological activities
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Isomer(s)
40743Liriodendrin
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Eleutheroside E

Item No. 29684

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[(1R,3aR,4S,6aS)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis(2,6-dimethoxy-4,1-phenylene)bis-β-D-glucopyranoside
CAS Number
39432-56-9
Synonyms
  • Syringin E
Molecular Formula
C34H46O18
Formula Weight
742.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 0.5mg/ml
SMILES
COC1=CC([C@]2([H])OC[C@]3([H])[C@](C4=CC(OC)=C(O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)C(OC)=C4)([H])OC[C@]32[H])=CC(OC)=C1O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6
InChi Code
InChI=1S/C34H46O18/c1-43-17-5-13(6-18(44-2)31(17)51-33-27(41)25(39)23(37)21(9-35)49-33)29-15-11-48-30(16(15)12-47-29)14-7-19(45-3)32(20(8-14)46-4)52-34-28(42)26(40)24(38)22(10-36)50-34/h5-8,15-16,21-30,33-42H,9-12H2,1-4H3/t15-,16+,21-,22-,23-,24-,25+,26+,27-,28-,29+,30-,33+,34+/m1/s1
InChi Key
FFDULTAFAQRACT-JSGUJALWSA-N
Origin
Plant/Eleutherococcus senticosus
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

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    50 mg

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    100 mg

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    250 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Eleutheroside E is a glycoside and major component of E. senticosus and has diverse biological activities.1 It protects against axonal and dendritic atrophies induced by amyloid-β (25-35) (Aβ (25-35); Item No. 24155) in primary rat cortical neurons.1,2,3,4 Eleutheroside E (15, 30, and 60 mg/kg) reduces macrophage infiltration, pannus formation, cartilage damage, bone erosion, and the production of TNF-α and IL-6 in a mouse model of collagen-induced arthritis.2 It increases insulin sensitivity and reduces pancreatic α- and β-cell death in db/db diabetic mice.3 Eleutheroside E (10 and 50 mg/kg) increases the latency to enter the dark chamber in a passive avoidance test and the levels of glutathione (GSH) in the hippocampus and decreases errors in the Y-maze test and hippocampal malondialdehyde (MDA) levels in a mouse model of sleep deprivation-induced stress.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bai, Y., Tohda, C., Zhu, S., et al. Active components from siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons. J. Nat. Med. 65(3-4), 417-423 (2011).

    2. He, C., Chen, X., Zhao, C., et al. Eleutheroside E ameliorates arthritis severity in collagen-induced arthritis mice model by suppressing inflammatory cytokine release. Inflammation 37(5), 1533-1543 (2014).

    3. Ahn, J., Um, M.Y., Lee, H., et al. Eleutheroside E, an active component of Eleutherococcus senticosus, ameliorates insulin resistance in type 2 diabetic db/db mice. Evid. Based Complement. Alternat. Med. 934183, (2013).

    4. Huang, L.-Z., Wei, L., Zhao, H.-F., et al. The effect of eleutheroside E on behavioral alterations in murine sleep deprivation stress model. Eur. J. Pharmacol. 658(2-3), 150-155 (2011).