An activator of KCa2/3 channels
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SKA-31

Item No. 29690

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
naphtho[1,2-d]thiazol-2-amine
CAS Number
40172-65-4
Synonyms
  • 2-Aminonaphthiazole
Molecular Formula
C11H8N2S
Formula Weight
200.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10mg/mLDMSO: 15mg/mLDMSO:PBS (pH 7.2) (1:5): 0.16mg/mLEthanol: 3mg/mL
SMILES
NC1=NC2=C(S1)C=CC3=CC=CC=C32
InChi Code
InChI=1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)
InChi Key
FECQXVPRUCCUIL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $43

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    10 mg

    $61

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    25 mg

    $140

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    50 mg

    $215

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    Product Description

    SKA-31 is an activator of the small- and intermediate conductance calcium-activated potassium channels KCa2.1, KCa2.2, KCa2.3, and KCa3.1 (EC50s = 2.9, 1.9, 2.9, and 0.26 µM, respectively, in a patch-clamp assay).1 It also blocks the voltage-gated potassium (Kv) channels Kv1.3, Kv1.5, Kv3.1, and Kv3.2 by 10 to 30% and the voltage-gated sodium (Nav) channels Nav1.2, Nav1.4, and Nav1.5 by 9 to 40% in a panel of 13 ion channels when used at a concentration of 25 µM. SKA-31 increases vasodilation induced by acetylcholine (Item No. 23829) in isolated mouse carotid artery (EC50 = 93 nM) and induces relaxation of isolated rat mesenteric artery rings precontracted with phenylephrine (IC50 = 93 nM).1,2 It decreases blood pressure in normotensive and angiotensin II-induced hypertensive mice when administered at a dose of 30 mg/kg.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sankaranarayanan, A., Raman, G., Busch, C., et al. Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol. Pharmacol. 75(2), 281-295 (2009).

    2. Khaddaj-Mallat, R., Mathew John, C., and Braun, A. SKA-31, an activator of endothelial Ca2+-activated K+ channels evokes robust vasodilation in rat mesenteric arteries. Eur. J. Pharmacol. 831, 60-67 (2018).