A saponin
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Notoginsenoside R1

Item No. 29691

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,6α,12β)-20-(β-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-β-D-xylopyranosyl-β-D-glucopyranoside
CAS Number
80418-24-2
Synonyms
  • Sanchinoside R1
Molecular Formula
C47H80O18
Formula Weight
933.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 10 mg/mlEthanol: 0.1 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)(C)CC/C=C(C)/C)(C)[C@]4(C)C[C@H](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)CO6)[C@@H](O)[C@H](O)[C@@H](CO)O5)[C@]7([H])[C@@](CC[C@H](O)C7(C)C)(C)[C@@]4([H])C1
InChi Code
InChI=1S/C47H80O18/c1-21(2)10-9-13-47(8,65-41-37(59)34(56)32(54)26(18-48)62-41)22-11-15-45(6)30(22)23(50)16-28-44(5)14-12-29(52)43(3,4)39(44)25(17-46(28,45)7)61-42-38(35(57)33(55)27(19-49)63-42)64-40-36(58)31(53)24(51)20-60-40/h10,22-42,48-59H,9,11-20H2,1-8H3/t22-,23+,24+,25-,26+,27+,28+,29-,30-,31-,32+,33+,34-,35-,36+,37+,38+,39-,40-,41-,42+,44+,45+,46+,47-/m0/s1
InChi Key
LLPWNQMSUYAGQI-OOSPGMBYSA-N
Origin
Plant/Panax notoginseng
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $80

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    10 mg

    $149

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    25 mg

    $351

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    50 mg

    $583

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Notoginsenoside R1 is a saponin that has been found in P. notoginseng and has diverse biological activities, including cardioprotective, neuroprotective, and anti-inflammatory properties.1 It decreases serum total cholesterol, triacylglycerol, and oxidized LDL (oxLDL) levels, as well as reduces atherosclerotic lesion area and lipid deposition in the aortic root of ApoE-/- mice fed a Western diet when administered at a dose of 25 mg/kg per day for eight weeks.2 Notoginsenoside R1 (100 mg/kg) inhibits apoptosis of hippocampal neurons and reduces infarct size in a rat model of cerebral ischemia-reperfusion injury induced by bilateral common carotid artery occlusion.3 It decreases colonic NF-ĸB and myeloperoxidase (MPO) activities and TNF-α and IL-6 levels, as well as reduces colonic shortening, tissue damage, and inflammatory cell infiltration in a mouse model of colitis induced by dextran sulfate sodium (DSS; Item No. 23250) when administered at a dose of 25 mg/kg per day for seven days.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, L., Zhang, J.-l., Sheng, Y.-x., et al. Simultaneous quantification of six major active saponins of Panax notoginseng by high-performance liquid chromatography-UV method. J. Pharm. Biomed. Anal. 38(1), 45-51 (2005).

    2. Jia, C., Xiong, M., Wang, P., et al. Notoginsenoside R1 attenuates atherosclerotic lesions in ApoE deficient mouse model. PLoS One 9(6), e99849 (2014).

    3. Zou, S., Zhang, M., Feng, L., et al. Protective effects of notoginsenoside R1 on cerebral ischemia-reperfusion injury in rats. Exp. Ther. Med. 14(6), 6012-6016 (2017).

    4. Zhang, J., Ding, L., Wang, B., et al. Notoginsenoside R1 attenuates experimental inflammatory bowel disease via pregnane X receptor activation. J. Pharmacol. Exp. Ther. 352(2), 315-324 (2015).