A flavonoid glycoside
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Epimedin B

Item No. 29694

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(6-deoxy-2-O-β-D-xylopyranosyl-α-L-mannopyranosyl)oxy]-7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
CAS Number
110623-73-9
Molecular Formula
C38H48O19
Formula Weight
808.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.14 mg/mlEthanol: 1 mg/ml
λmax
272, 316 nm
SMILES
O=C1C(O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O)CO3)[C@H](O)[C@@H](O)[C@H](C)O2)=C(C4=CC=C(OC)C=C4)OC5=C1C(O)=CC(O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)=C5C/C=C(C)\C
InChi Code
InChI=1S/C38H48O19/c1-14(2)5-10-18-21(53-37-31(49)28(46)26(44)22(12-39)54-37)11-19(40)23-27(45)34(32(55-33(18)23)16-6-8-17(50-4)9-7-16)56-38-35(29(47)24(42)15(3)52-38)57-36-30(48)25(43)20(41)13-51-36/h5-9,11,15,20,22,24-26,28-31,35-44,46-49H,10,12-13H2,1-4H3/t15-,20+,22+,24-,25-,26+,28-,29+,30+,31+,35+,36-,37+,38-/m0/s1
InChi Key
OCZZCFAOOWZSRX-LRHLXKJSSA-N
Origin
Plant/Longspur epimedium
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $72

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    10 mg

    $123

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    25 mg

    $269

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    50 mg

    $429

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    Product Description

    Epimedin B is a flavonoid glycoside that has been found in E. koreanum and has antioxidant, anti-osteoporotic, and anti-inflammatory activities.1,2,3,4,5 It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 107.9 µM).2 Epimedin B increases proliferation of UMR-106 osteoblasts by 24.9 and 36.3% when used at concentrations of 10 and 100 µM, respectively.3 It prevents osteoporosis induced by prednisolone (Item No. 20866) in zebrafish when used at a concentration of 1 µM.4 Epimedin B inhibits ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice (ED50 = 114 nmol/ear).5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ito, Y., Hirayama, F., Suto, K., et al. Three flavonol glycosides from Epimedium koreanum. Phytochemistry 27(3), 911-913 (1988).

    2. Kim, E.S., Kim, M.K., Kang, H.K., et al. Flavonol glycosides with antioxidant activity from the aerial parts of Epimedium koreanum nakai. Nat. Prod. Sci. 14(4), 233-238 (2008).

    3. Meng, F.-H., Li, Y.-B., Xiong, A.-L., et al. Osteoblastic proliferative activity of Epimedium brevicornum maxim. Phytomedicine 12(3), 189-193 (2005).

    4. Zhan, Y., Wei, Y.-J., Wang, C.-M., et al. Evaluation of antiosteoporotic activity for micro amount icariin and epimedin B based on the osteoporosis model using zebrafish. Journal of Chinese Pharmaceutical Sciences 49(1), 30-35 (2014).

    5. Yasukawa, K., Ko, S.-K., and Whang, W.-K. Inhibitory effects of the aerial parts of Epimedium koreanum on TPA-induced inflammation and tumour promotion in two-stage carcinogenesis in mouse skin. J. Pharm. Nutr. Sci. 6(2), 38-42 (2016).