A PPARγ agonist
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S26948

Item No. 29722

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-[2-(6-benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-propanedioic acid, 1,3-dimethyl ester
CAS Number
353280-43-0
Molecular Formula
C28H25NO7S
Formula Weight
519.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=C1N(CCOC2=CC=C(CC(C(OC)=O)C(OC)=O)C=C2)C(C=CC(C(C3=CC=CC=C3)=O)=C4)=C4S1
InChi Code
InChI=1S/C28H25NO7S/c1-34-26(31)22(27(32)35-2)16-18-8-11-21(12-9-18)36-15-14-29-23-13-10-20(17-24(23)37-28(29)33)25(30)19-6-4-3-5-7-19/h3-13,17,22H,14-16H2,1-2H3
InChi Key
NSMJEHGOMXSLCW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $154

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    S26948 is a peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 8.83 nM in a transactivation assay).1 It is selective for PPARγ over PPARα, PPARβ/δ, and retinoid X receptor α (RXRα) at 10 μM. S26948 (30 mg/kg per day) decreases serum levels of glucose, triglycerides, non-esterified fatty acids, and insulin and increases hepatic palmitate oxidation in an ob/ob mouse model of type 2 diabetes. It decreases plasma levels of triglycerides and total and non-HDL cholesterol and the surface area of atherosclerotic lesions in the aortic sinus in an E2-KI transgenic mouse model of dyslipidemia and atherosclerosis fed a Western diet when administered at a dose of 30 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Carmona, M.C., Louche, K., Lefebvre, B., et al. S 26948: A new specific peroxisome proliferator-activated receptor γ modulator with potent antidiabetes and antiatherogenic effects. Diabetes 56(11), 2797-2808 (2007).