A CXCR3 antagonist
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CXCR3 Antagonist 6c

Item No. 29731

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-[(3-chlorobenzoyl)amino]-4-[[[2-(2,4-dichlorophenyl)ethyl]amino]carbonyl]phenyl]-N-ethylhexahydro-1H-1,4-diazepine-1-carboxamide
CAS Number
870998-13-3
Molecular Formula
C30H32Cl3N5O3
Formula Weight
617.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: >100mM
SMILES
ClC1=CC=CC(C(NC2=CC(C(NCCC3=C(Cl)C=C(Cl)C=C3)=O)=CC=C2N4CCCN(C(NCC)=O)CC4)=O)=C1
InChi Code
InChI=1S/C30H32Cl3N5O3/c1-2-34-30(41)38-14-4-13-37(15-16-38)27-10-8-22(18-26(27)36-29(40)21-5-3-6-23(31)17-21)28(39)35-12-11-20-7-9-24(32)19-25(20)33/h3,5-10,17-19H,2,4,11-16H2,1H3,(H,34,41)(H,35,39)(H,36,40)
InChi Key
VPDHCRDNIQTCFU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $238

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    10 mg

    $392

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    Product Description

    CXCR3 antagonist 6c is an antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3).1 It inhibits calcium mobilization induced by chemokine (C-X-C motif) ligand 11 (CXCL11) in HEK293 cells expressing the human receptor (IC50 = 0.06 µM). It is selective for CXCR3 over a panel of 14 human G protein-coupled receptors at 10 µM. CXCR3 antagonist 6c inhibits CXCR3-mediated migration of isolated human T cells (IC50 = ~100 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cole, A.G., Stroke, I.L., Brescia, M.-R., et al. Identification and initial evaluation of 4-N-aryl-[1,4]diazepane ureas as potent CXCR3 antagonists. Bioorg. Med. Chem. Lett. 16(1), 200-203 (2006).