A dual antagonist of 5-HT2A and σ2 receptors
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CYR-101

Item No. 29773

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[1-[2-(4-fluorophenyl)-2-oxoethyl]-4-piperidinyl]methyl]-2,3-dihydro-1H-isoindol-1-one
CAS Number
359625-79-9
Molecular Formula
C22H23FN2O2
Formula Weight
366.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10mg/mLDMF:PBS (pH 7.2) (1:3): 0.25mg/mLDMSO: 5mg/mLEthanol: 3mg/mL
λmax
229, 244 nm
SMILES
O=C1N(CC2CCN(CC(C3=CC=C(F)C=C3)=O)CC2)CC4=CC=CC=C41
InChi Code
InChI=1S/C22H23FN2O2/c23-19-7-5-17(6-8-19)21(26)15-24-11-9-16(10-12-24)13-25-14-18-3-1-2-4-20(18)22(25)27/h1-8,16H,9-15H2
InChi Key
RNRYULFRLCBRQS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $117

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    25 mg

    $230

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    50 mg

    $400

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    100 mg

    $684

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    Product Description

    CYR-101 is a dual antagonist of the serotonin (5-HT) receptor subtype 5-HT2A and sigma-2 (σ2) receptors (Kis = 7.53 and 8.19 nM, respectively).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Davidson, M., Saoud, J., Staner, C., et al. Efficacy and safety of MIN-101: A 12-week randomized, double-blind, placebo-controlled trial of a new drug in development for the treatment of negative symptoms in schizophrenia. Am. J. Psychiatry 174(12), 1195-1202 (2017).