A β1-AR antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Bevantolol (hydrochloride)

Item No. 29792

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-2-propanol, monohydrochloride
CAS Number
42864-78-8
Synonyms
  • CI-755
  • DL-Bevantolol
  • NC-1400
Molecular Formula
C20H27NO4 • HCl
Formula Weight
381.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml
SMILES
CC1=CC=CC(OCC(O)CNCCC2=CC(OC)=C(OC)C=C2)=C1.Cl
InChi Code
InChI=1S/C20H27NO4.ClH/c1-15-5-4-6-18(11-15)25-14-17(22)13-21-10-9-16-7-8-19(23-2)20(12-16)24-3;/h4-8,11-12,17,21-22H,9-10,13-14H2,1-3H3;1H
InChi Key
FJTKCFSPYUMXJB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 mg

    $134

    Add

    250 mg

    $251

    Add

    500 mg

    $432

    Add
    Product Description

    Bevantolol is an antagonist of the β1-adrenergic receptor (β1-AR; Ki = 14.79 nM in rat cortical membranes).1 It is selective for β1- over β2-ARs (Ki = 588.84 nM), as well as α2-ARs up to 100 μM, but is an antagonist of α1-ARs (Ki = 125.89 nM). Bevantolol inhibits low voltage-activated calcium currents (LVA-ICa) in dissociated rat ventro-medial hypothalamic neurons (IC50 = 40 μM).2 It inhibits norepinephrine-induced contraction of isolated rabbit thoracic aorta (pA2 = 4.77), isoprenaline-induced inotropic effects in isolated guinea pig right atria (pA2 = 7.74), and isoprenaline-induced relaxation of isolated guinea pig trachea (pA2 = 6.69).3 Bevantolol (250 mg/kg per day) prevents immobilization stress-induced increases in systolic blood pressure in a rat model of stress-induced hypertension.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Takita, M., Kigoshi, S., and Muramatsu, I. Selectivity of bevantolol hydrochloride towards ɑ and β-adrenoceptor subtypes in rat cerebral cortex. Jpn. J. Pharmacol. 58(2), 193-196 (1992).

    2. T., O., Kobayashi, T., Nishioka, K., et al. Ca2+-antagonistic action of bevantolol on hypothalamic neurons in vitro: Its comparison with those of other β-adrenoceptor antagonists, a local anesthetic and a Ca2+-antagonist. Brain Res. 706(2), 289-292 (1996).

    3. Takayanagi, I., Kizawa, Y., Iwasaki, S., et al. (+/-)-1-[[2-(3,4-dimethoxphenyl)ethyl]amino]-3-(3-methylphenoxy)-2-propanol hydrochloride (bevantolol, NC-1400) as a β1-selective adrenoceptor blocker With ɑ1-adrenoceptor Blocking Activity. Gen. Pharmacol. 18(1), 87-90 (1987).

    4. Takita, M., Kigoshi, S., and Muramatsu, I. Effects of bevantolol HCl on immobilization stress-induced hypertension and central β-adrenoceptors in rats. Pharmacol. Biochem. Behav. 45, 623-627 (1993).