A TLR8 antagonist
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CU-115

Item No. 29815

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodo-benzamide
CAS Number
2471982-20-2
Molecular Formula
C21H11F7INO2
Formula Weight
569.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10mg/mLDMSO: 10mg/mLDMSO:PBS (pH 7.2) (1:5): 0.15mg/mLEthanol: 0.25mg/mL
SMILES
O=C(NC1=CC=C(OC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C=C1)C3=C(I)C=CC=C3F
InChi Code
InChI=1S/C21H11F7INO2/c22-16-2-1-3-17(29)18(16)19(31)30-13-4-6-14(7-5-13)32-15-9-11(20(23,24)25)8-12(10-15)21(26,27)28/h1-10H,(H,30,31)
InChi Key
QYSLCRYVUJORPX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    CU-115 is a toll-like receptor 8 (TLR8) antagonist (IC50 = 1.04 µM).1 It is selective for TLR8 over TLR7 (IC50 = >50 µM). CU-115 inhibits increases in type I IFN transcriptional activity induced by the ssRNA nucleic acid ligands 3p-hpRNA or G3-YSD in a luciferase reporter assay when used at concentrations of 5 and 20 µM. It decreases TNF-α and IL-1β production induced by R-848 (Item No. 14806) in THP-1 cells when used at a concentration of 5 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Padilla-Salinas, R., Anderson, R., Sakaniwa, K., et al. Discovery of novel small molecule dual inhibitors targeting toll-like receptors 7 and 8. J. Med. Chem. 62(22), 10221-10244 (2019).