A sesquiterpene
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Drimendiol

Item No. 29820

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-1,2-naphthalenedimethanol
CAS Number
34437-62-2
Molecular Formula
C15H26O2
Formula Weight
238.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly Soluble: 0.1-1 mg/ml
SMILES
OC[C@H]1C(CO)=CC[C@@]2([H])C(C)(C)CCC[C@@]21C
InChi Code
InChI=1S/C15H26O2/c1-14(2)7-4-8-15(3)12(10-17)11(9-16)5-6-13(14)15/h5,12-13,16-17H,4,6-10H2,1-3H3/t12-,13-,15+/m0/s1
InChi Key
KUTDAKOPPDXZDV-KCQAQPDRSA-N
Origin
Semi-synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Drimendiol is a sesquiterpene that has been found in W. ugandensis.1 It inhibits C. albicans, S. aureus, and S. epidermidis biofilm formation with 50% biofilm inhibitory concentration values (BIC50s) of 25.5, 65.1, and 67.1 µg/ml, respectively. It has antifouling activity, inhibiting the settlement of C. savignyi and B. improvisus larvae on a petri dish surface (EC50s = 1 and 0.5 µg/ml, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kipanga, P.N., Liu, M., Panda, S.K., et al. Biofilm inhibiting properties of compounds from the leaves of Warburgia ugandensis Sprague subsp ugandensis against Candida and staphylococcal biofilms. J. Ethnopharmacol. 248:112352, (2020).

    2. Moodie, L.W., Trepos, R., Cervin, G., et al. Probing the structure-activity relationship of the natural antifouling agent polygodial against both micro- and macrofoulers by semisynthetic modification. J. Nat. Prod. 80(2), 515-525 (2017).