A LRRK2 inhibitor
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CID-25014542

Item No. 29837

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-chloro-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one
CAS Number
220904-99-4
Molecular Formula
C15H8Br2ClNO2
Formula Weight
429.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
ClC1=CC=C2C(/C(C(N2)=O)=C/C3=CC(Br)=C(O)C(Br)=C3)=C1
InChi Code
InChI=1S/C15H8Br2ClNO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
InChi Key
MPIHOJMBMIMKAJ-KMKOMSMNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $72

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    10 mg

    $137

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    25 mg

    $323

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    50 mg

    $572

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    Product Description

    CID-25014542 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 15 nM).1 It is selective for LRRK2 over a panel of 44 other kinases but does inhibit MAPK4 and Pim-2 at 1 µM. CID-25014542 (10 µM) also inhibits FMS-related tyrosine kinase 3 (FLT3). It decreases the production of amyloid-β (1-42) (Aβ42) in a reporter assay using H4 cells overexpressing Aβ42 (IC50 = 15 µM). CID-25014542 (20 µM) inhibits EGF-induced activation of MAPK in serum-starved cells.2 It increases the survival of primary rat granule neurons in low potassium media when used at concentrations of 1, 5, or 25 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Göring, S., Taymans, J.M., Baekelandt, V., et al. Indolinone based LRRK2 kinase inhibitors with a key hydrogen bond. Bioorg. Med. Chem. Lett. 24(19), 4630-4637 (2014).

    2. Wood, E., Crosby, R.M., Dickerson, S., et al. A prodrug approach to the design of cRaf1 kinase inhibitors with improved cellular activity. Anticancer Drug Des. 16(1), 1-6 (2001).

    3. Balderamos, M., Ankati, H., Akubathini, S.K., et al. Synthesis and structure-activity relationship studies of 3-substituted indolin-2-ones as effective neuroprotective agents. Exp. Biol. Med. (Maywood) 233(11), 1395-1402 (2008).